Immunology of a Transmissible Cancer Spreading among Tasmanian Devils
نویسندگان
چکیده
منابع مشابه
A second transmissible cancer in Tasmanian devils.
Clonally transmissible cancers are somatic cell lineages that are spread between individuals via the transfer of living cancer cells. There are only three known naturally occurring transmissible cancers, and these affect dogs, soft-shell clams, and Tasmanian devils, respectively. The Tasmanian devil transmissible facial cancer was first observed in 1996, and is threatening its host species with...
متن کاملRapid evolutionary response to a transmissible cancer in Tasmanian devils
Although cancer rarely acts as an infectious disease, a recently emerged transmissible cancer in Tasmanian devils (Sarcophilus harrisii) is virtually 100% fatal. Devil facial tumour disease (DFTD) has swept across nearly the entire species' range, resulting in localized declines exceeding 90% and an overall species decline of more than 80% in less than 20 years. Despite epidemiological models t...
متن کاملTransmissible cancer in Tasmanian devils: localized lineage replacement and host population response.
Tasmanian devil facial tumour disease (DFTD) is a clonally transmissible cancer threatening the Tasmanian devil (Sarcophilus harrisii) with extinction. Live cancer cells are the infectious agent, transmitted to new hosts when individuals bite each other. Over the 18 years since DFTD was first observed, distinct genetic and karyotypic sublineages have evolved. In this longitudinal study, we inve...
متن کاملDFTD: A Contagious Fatal Cancer that Threatens the Tasmanian Devils
The fact that Tasmanian devils are prone to a bizarre type of contagious facial cancer disease was first noted in 1996 in the far north east of Tasmania, and since then, the disease has spread south and west and now affects devils in over 85% of their distribution territory [1,2]. The disease, termed devil facial tumor disease (DFTD), is spread by biting, causing the appearance of tumors on the...
متن کاملImmunoglubolin dynamics and cancer prevalence in Tasmanian devils (Sarcophilus harrisii)
Immunoglobulins such as IgG and IgM have been shown to induce anti-tumour cytotoxic activity. In the present study we therefore explore total serum IgG and IgM expression dynamics in 23 known-aged Tasmanian devils (Sarcophilus harrisii) of which 9 where affected by Devil Facial Tumour Disease (DFTD). DFTD is clonally transmissible cancer that has caused massive declines in devil numbers. Our an...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2015
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.1500131